El-Tanbouly, D., Zaki, H., Abdelsalam, R., Zaki, A. (2019). Anti-inflammatory and Anti-apoptotic Potentials of Apigenin against Liver Injury Induced by Ischemia-Reperfusion in Rats. Bulletin of Faculty of Pharmacy, Cairo University, 57(1), 46-54. doi: 10.21608/bfpc.2019.13703.1040
Dalia El-Tanbouly; hala Zaki; Rania Abdelsalam; Aya Zaki. "Anti-inflammatory and Anti-apoptotic Potentials of Apigenin against Liver Injury Induced by Ischemia-Reperfusion in Rats". Bulletin of Faculty of Pharmacy, Cairo University, 57, 1, 2019, 46-54. doi: 10.21608/bfpc.2019.13703.1040
El-Tanbouly, D., Zaki, H., Abdelsalam, R., Zaki, A. (2019). 'Anti-inflammatory and Anti-apoptotic Potentials of Apigenin against Liver Injury Induced by Ischemia-Reperfusion in Rats', Bulletin of Faculty of Pharmacy, Cairo University, 57(1), pp. 46-54. doi: 10.21608/bfpc.2019.13703.1040
El-Tanbouly, D., Zaki, H., Abdelsalam, R., Zaki, A. Anti-inflammatory and Anti-apoptotic Potentials of Apigenin against Liver Injury Induced by Ischemia-Reperfusion in Rats. Bulletin of Faculty of Pharmacy, Cairo University, 2019; 57(1): 46-54. doi: 10.21608/bfpc.2019.13703.1040
Anti-inflammatory and Anti-apoptotic Potentials of Apigenin against Liver Injury Induced by Ischemia-Reperfusion in Rats
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Abstract
Apigenin is a dietary flavonoid that exists copiously in several herbs and vegetables. It exhibits anti-inflammatory, anti-mutagenesis, anti-proliferative and antioxidant properties. The present work aimed to investigate some of mechanisms underlying protective potential of apigenin in hepatic ischemia-reperfusion injury. Rats were divided into four groups; sham-operated, sham-operated pretreated with apigenin (25 mg/kg, p.o.), ischemia/reperfusion (I/R) (30 min ischemia and 1 h reperfusion) and I/R pretreated with apigenin. Compared with I/R group, pretreatment with apigenin markedly reduced transaminases levels and ameliorated tissue histopathological changes. Apigenin significantly reduced high mobility group box 1 (HMGB1) expression and suppressed liver tumor necrosis factor- α (TNF-α), nuclear factor κB (NF-κB) and myeloperoxidase (MPO) activity. Moreover, apigenin restored reduced glutathione (GSH), decreased liver lipid peroxidation, and boosted glutathione peroxidase (GPx) activity in addition to attenuation of apoptosis by increasing Bcl-2/Bax ratio. It may thus be concluded that inhibition of HMGBI by apigenin plays a role towards its antioxidant, anti-inflammatory as well as anti-apoptotic properties which are involved in conferring its hepato-protective properties
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