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Bulletin of Faculty of Pharmacy, Cairo University
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Journal Archive
Volume Volume 57 (2019)
Issue Issue 2
Issue Issue 1
Alsammarraie, H., Khan, N., Mahmud, R., Bin Asmawi, M., Murugaiyah, V. (2019). Preformulation, stress stability studies and HPLC-UV method development and validation for 95 % ethanol extract of Moringa oleifera Lam. Leaves. Bulletin of Faculty of Pharmacy, Cairo University, 57(2), 114-126. doi: 10.21608/bfpc.2019.101867
Harith Jameel Mahdi Alsammarraie; Nurzalina Abdul Karim Khan; Roziahanim Mahmud; Mohd Zaini Bin Asmawi; Vikneswaran A/L Murugaiyah. "Preformulation, stress stability studies and HPLC-UV method development and validation for 95 % ethanol extract of Moringa oleifera Lam. Leaves". Bulletin of Faculty of Pharmacy, Cairo University, 57, 2, 2019, 114-126. doi: 10.21608/bfpc.2019.101867
Alsammarraie, H., Khan, N., Mahmud, R., Bin Asmawi, M., Murugaiyah, V. (2019). 'Preformulation, stress stability studies and HPLC-UV method development and validation for 95 % ethanol extract of Moringa oleifera Lam. Leaves', Bulletin of Faculty of Pharmacy, Cairo University, 57(2), pp. 114-126. doi: 10.21608/bfpc.2019.101867
Alsammarraie, H., Khan, N., Mahmud, R., Bin Asmawi, M., Murugaiyah, V. Preformulation, stress stability studies and HPLC-UV method development and validation for 95 % ethanol extract of Moringa oleifera Lam. Leaves. Bulletin of Faculty of Pharmacy, Cairo University, 2019; 57(2): 114-126. doi: 10.21608/bfpc.2019.101867

Preformulation, stress stability studies and HPLC-UV method development and validation for 95 % ethanol extract of Moringa oleifera Lam. Leaves

Article 2, Volume 57, Issue 2, Summer and Autumn 2019, Page 114-126  XML PDF (238.51 K)
Document Type: Original Article
DOI: 10.21608/bfpc.2019.101867
Authors
Harith Jameel Mahdi Alsammarraieorcid 1, 2; Nurzalina Abdul Karim Khan3; Roziahanim Mahmud4; Mohd Zaini Bin Asmawi5; Vikneswaran A/L Murugaiyah5
1Department of Pharmaceutical Technology, School of pharmaceutical Sciences, USM, Malaysia.+
2Department of Applied Chemistry, Faculty of Applied Sciences, University of Samarra, Iraq.
3Department of Pharmaceutical Technology, School of pharmaceutical Sciences, USM, Malaysia.
4Department of Pharmaceutical Chemistry, School of pharmaceutical Sciences, USM, Penang, Malaysia.
5Department of Pharmacology, School of pharmaceutical Sciences, USM, Penang, Malaysia.
Abstract
Introduction: There is a continuous expansion in number of botanical medicinal products and increase in consumers who often use it. One of such natural source products with versatile traditional uses as treatment for variety of diseases is Moringa oleifera Lam. Objectives: After the pharmacological activity of a new drug candidate is approved, the subsequent development of this product requires substantial information about its physical and chemical properties before designing its dosage form. Methods: Organoleptic properties, physicochemical characteristics, solubility profile, swelling index, partition coefficient, analyses of thermal behaviour, stress stability, heavy metals and microbial limit tests were performed in preformulation studies of 95 % ethanol extract of M. oleifera leaves. Results: The results of preformulation studies illustrated several characteristic properties that should be consider during formulation of Moringa extract. In addition to that, a HPLC-UV method for simultaneous detection and quantification of three reference markers was developed and validated. Conclusion: The 95 % ethanol extract of Moringa leaf is relevant to the development of phytomedicines, dietary supplements or cosmetics. To the best of our knowledge, the present study is the first preformulation study which aimed to determine the physicochemical properties of 95 % ethanol extract of Moringa oleifera leaf.
Keywords
HPLC-UV; moringa oleifera; preformulation study; Stress stability
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